2N7N : NMR structure of Peptide PG-989 in DPC micelles

  • Alfonso Carotenuto (Contributor)
  • Francesco Merlino (Contributor)
  • Minying Cai (Contributor)
  • Diego Brancaccio (Contributor)
  • Ali Munaim Yousif (Contributor)
  • Ettore Novellino (Contributor)
  • Victor J. Hruby (Contributor)
  • Paolo Grieco (Contributor)



Experimental Technique/Method:SOLUTION NMR
Classification:DE NOVO PROTEIN
Release Date:2015-12-16
Deposition Date:2015-09-16
Revision Date:2016-01-06#2017-10-11
Molecular Weight:1084.29
Macromolecule Type:Protein
Residue Count:10
Atom Site Count:78

The melanocortin receptors 3 and 4 control energy homeostasis, food-intake behavior, and correlated pathophysiological conditions. The melanocortin-4 receptor (MC4R) has been broadly investigated. In contrast, the knowledge related to physiological roles of the melanocortin-3 receptor (MC3R) is lacking because of the limited number of known MC3R selective ligands. Here, we report the design, synthesis, biological activity, conformational analysis, and docking with receptors of two potent and selective agonists at the human MC3 receptor.
Date made available2015

Cite this