Description
Experimental Technique/Method:SOLUTION NMR
Resolution:
Classification:DNA
Release Date:2009-12-15
Deposition Date:2009-06-16
Revision Date:2011-07-13#2014-09-17
Molecular Weight:7272.68
Macromolecule Type:DNA
Residue Count:23
Atom Site Count:484
DOI:10.2210/pdb2kka/pdb
Abstract:
Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
Resolution:
Classification:DNA
Release Date:2009-12-15
Deposition Date:2009-06-16
Revision Date:2011-07-13#2014-09-17
Molecular Weight:7272.68
Macromolecule Type:DNA
Residue Count:23
Atom Site Count:484
DOI:10.2210/pdb2kka/pdb
Abstract:
Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
| Date made available | 2009 |
|---|---|
| Publisher | RCSB-PDB |