2KKA : Human telomere DNA two-tetrad quadruplex structure in K+ solution

  • Zhenjiang Zhang (Contributor)
  • Jixun Dai (Contributor)
  • Danzhou Yang (Contributor)



Experimental Technique/Method:SOLUTION NMR
Release Date:2009-12-15
Deposition Date:2009-06-16
Revision Date:2011-07-13#2014-09-17
Molecular Weight:7272.68
Macromolecule Type:DNA
Residue Count:23
Atom Site Count:484

Human telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. The telomeric sequence shows intrinsic structure polymorphism. Here we report a novel intramolecular G-quadruplex structure formed by a variant human telomeric sequence in K(+) solution. This sequence forms a basket-type intramolecular G-quadruplex with only two G-tetrads but multiple-layer capping structures formed by loop residues. While it is shown that this structure can only be detected in the specifically truncated telomeric sequences without any 5'-flanking residues, our results suggest that this two-G-tetrad conformation is likely to be an intermediate form of the interconversion of different telomeric G-quadruplex conformations.
Date made available2009

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