Description
Experimental Technique/Method:X-RAY DIFFRACTION
Resolution:1.5
Classification:TRANSPORT PROTEIN
Release Date:1998-08-05
Deposition Date:1998-07-29
Revision Date:2008-04-27#2011-07-13#2017-10-04
Molecular Weight:20926.18
Macromolecule Type:Protein
Residue Count:184
Atom Site Count:1472
DOI:10.2210/pdb1np4/pdb
Abstract:
Nitrophorins are nitric oxide (NO) transport proteins from the saliva of blood-feeding insects, which act as vasodilators and anti-platelet agents. Rhodnius prolixus, an insect that carries the trypanosome that causes Chagas' disease, releases four NO-loaded nitrophorins during blood feeding, whereupon the ligand is released into the bloodstream or surrounding tissue of the host. Histamine, a signaling molecule released by the host upon tissue damage, is tightly bound by the nitrophorins; this may facilitate the release of NO and reduce inflammation in the host.
Resolution:1.5
Classification:TRANSPORT PROTEIN
Release Date:1998-08-05
Deposition Date:1998-07-29
Revision Date:2008-04-27#2011-07-13#2017-10-04
Molecular Weight:20926.18
Macromolecule Type:Protein
Residue Count:184
Atom Site Count:1472
DOI:10.2210/pdb1np4/pdb
Abstract:
Nitrophorins are nitric oxide (NO) transport proteins from the saliva of blood-feeding insects, which act as vasodilators and anti-platelet agents. Rhodnius prolixus, an insect that carries the trypanosome that causes Chagas' disease, releases four NO-loaded nitrophorins during blood feeding, whereupon the ligand is released into the bloodstream or surrounding tissue of the host. Histamine, a signaling molecule released by the host upon tissue damage, is tightly bound by the nitrophorins; this may facilitate the release of NO and reduce inflammation in the host.
| Date made available | 1998 |
|---|---|
| Publisher | RCSB-PDB |