1ERW : HUMAN THIOREDOXIN DOUBLE MUTANT WITH CYS 32 REPLACED BY SER AND CYS 35 REPLACED BY SER

  • Andrzej Weichsel (Contributor)
  • John R. Gasdaska (Contributor)
  • Garth Powis (Contributor)
  • William R Montfort (Contributor)

Dataset

Description

Experimental Technique/Method:X-RAY DIFFRACTION
Resolution:1.8
Classification:OXIDOREDUCTASE
Release Date:1996-10-14
Deposition Date:1996-02-07
Revision Date:2008-03-24#2011-07-13
Molecular Weight:11718.35
Macromolecule Type:Protein
Residue Count:105
Atom Site Count:826
DOI:10.2210/pdb1erw/pdb

Abstract:
Human thioredoxin reduces the disulfide bonds of numerous proteins in vitro, and can activate transcription factors such as NFkB in vivo. Thioredoxin can also act as a growth factor, and is overexpressed and secreted in certain tumor cells.
Date made available1996
PublisherRCSB-PDB

Access Dataset

Cite this